{"id":8670,"date":"2023-10-01T17:05:27","date_gmt":"2023-10-01T08:05:27","guid":{"rendered":"https:\/\/www.cobaring.com\/?p=8670"},"modified":"2025-01-09T09:33:20","modified_gmt":"2025-01-09T00:33:20","slug":"%e3%81%aa%e3%81%9c%e6%ad%af%e5%91%a8%e7%97%85%e3%81%ab%e3%81%aa%e3%82%8b%e3%81%ae%e3%81%8b","status":"publish","type":"post","link":"https:\/\/www.cobaring.com\/?p=8670","title":{"rendered":"\u306a\u305c\u6b6f\u5468\u75c5\u306b\u306a\u308b\u306e\u304b"},"content":{"rendered":"<p>\u53c2\u7167\u52d5\u753b <a href=\"https:\/\/www.youtube.com\/watch?v=h21oyM7R_KY&amp;t=544s\">\u5409\u91ce\u654f\u660e\u30c1\u30e3\u30f3\u30cd\u30eb\uff5e\u65e5\u672c\u306e\u75c5\u3092\u6cbb\u3059\uff5e\u300c\u306a\u305c\u6b6f\u5468\u75c5\u306b\u306a\u308b\u306e\u304b\u300d<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-8664\" src=\"https:\/\/www.cobaring.com\/wp-content\/uploads\/2023\/10\/20231001_124442.gif\" alt=\"\" width=\"388\" height=\"640\" \/><\/a><\/p>\n<div id=\"mokuji\">\n<div class=\"post mokuji\">\u00a0<\/div>\n<\/div>\n<p><span style=\"color: midnightblue;\"><span style=\"font-size: 18pt;\">\u306a\u305c\u6b6f\u5468\u75c5\u306b\u306a\u308b\u306e\u304b<\/span><\/span><\/p>\n<h2>\u6b6f\u69fd\u81bf\u6f0f<\/h2>\n<p>\u4ee5\u524d\u306f\u6b6f\u69fd\u81bf\u6f0f\u3068\u547c\u3093\u3067\u3044\u305f\u3002\u6b6f\u830e\u304b\u3089\u81bf\u304c\u6f0f\u308c\u308b\u3068\u3044\u3046\u75c7\u72b6\u3060\u304b\u3089\u3067\u3059\u3002<br \/>\u7a81\u767a\u6027\u96e3\u8074\u3084\u98db\u868a\u75c7\u3068\u304b\u3068\u540c\u3058\u3067\u6f20\u7136\u3068\u3057\u305f\u75c5\u540d\u3060\u3063\u305f\u306e\u3067\u3059\u3002<br \/>\u306a\u305c\u305d\u306e\u6b6f\u5468\u75c5\u306e\u3053\u3068\u3092<span style=\"color: midnightblue;\">\u6b6f\u69fd\u81bf\u6f0f<\/span>\u3068\u8a00\u3063\u3066\u3044\u305f\u304b\u3068\u3044\u3046\u3068\u539f\u56e0\u304c\u89e3\u3089\u306a\u304b\u3063\u305f\u304b\u3089\u3067\u3059\u3002<br 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coral;\">\u597d\u6c17\u6027\u83cc\u306e\u591a\u304f\u306f\u866b\u6b6f\u306e\u539f\u56e0\u306b\u306a\u308b\u30d0\u30a4\u83cc\u306a\u3069\u304c\u8a72\u5f53\u3057\u3001\u6240\u8b02\u866b\u6b6f\u83cc\u3068\u3044\u3046\u306e\u306f\u7802\u7cd6\u3092\u990c\u306b\u3059\u308b<\/span>\u306e\u3067\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-8665\" src=\"https:\/\/www.cobaring.com\/wp-content\/uploads\/2023\/10\/20231001_124247.gif\" alt=\"\" width=\"388\" height=\"640\" \/><br \/>\u7518\u3044\u3082\u306e\u3092\u98df\u3079\u3066\u3044\u308b\u3068\u305d\u308c\u304c\u6b6f\u306e\u8868\u9762\u306b\u4ed8\u3044\u3066\u7802\u7cd6\u3092\u98df\u3079\u3066\u3001\u4e73\u9178\u3092\u6392\u6cc4\u3059\u308b\u306e\u3067\u3059\u3002<br \/>\u6b6f\u306e\u8868\u9762\u304c\u4e73\u9178\u3067\u6eb6\u3051\u3066\u7a74\u304c\u958b\u304f\u3068\u3044\u3046\u306e\u304c\u866b\u6b6f\u3067\u3059\u3002<br \/><span style=\"color: coral;\">\u6df1\u3044\u3068\u3053\u308d\u306b\u5165\u3063\u305f\u3089<\/span>\u7802\u7cd6\u304c\u5165\u3063\u3066\u304f\u308b\u304b\u3068\u3044\u3046\u3068\u5165\u3063\u3066\u304f\u308b\u3053\u3068\u306f\u306a\u304f\u3001<span style=\"color: coral;\">\u8840\u6db2\u3068\u304b\u6b6f\u8089\u305d\u306e\u3082\u306e\u3001\u86cb\u767d\u8cea\u306a\u3069\u3092\u990c\u306b\u3057\u307e\u3059\u3002<\/span><\/p>\n<p>\u4f8b\u3048\u3070<strong>\u30b3\u30e9\u30b2\u30ca\u30fc\u30bc\uff08Collagenase\uff09\u3068\u3044\u3046\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u304c\u9aa8\u3092\u6eb6\u304b\u3057\u307e\u3059\u3002<br \/>\u30b8\u30f3\u30b8\u30d1\u30a4\u30f3\uff08gingipains\uff09\u3068\u3044\u3046\u9175\u7d20\u306f\u6b6f\u8089\u306b\u7a74\u3092\u958b\u3051\u307e\u3059\u3002<\/strong><br \/>\u3053\u3046\u3044\u3063\u305f<span style=\"color: coral;\">\u86cb\u767d\u5206\u89e3\u9175\u7d20\u306a\u3069\u3084\u9aa8\u3092\u5206\u89e3\u3059\u308b\u3088\u3046\u306a\u9175\u7d20\u3092\u51fa\u3057\u3066\u3001\u305d\u306e\u6b6f\u5468\u7d44\u7e54\u3092\u7834\u58ca\u3059\u308b<\/span>\u306e\u3067\u3059\u3002<br \/>\u6b6f\u5468\u7d44\u7e54\u3068\u3044\u3046\u306e\u306f\u6b6f\u8089\u3068\u6b6f\u69fd\u9aa8\u3068\u30bb\u30e1\u30f3\u30c8\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u304c\u3001\u3053\u3046\u3044\u3063\u305f\u3068\u3053\u308d\u3092\u58ca\u3059\u306e\u3067\u3059\u3002<br \/>\u6b6f\u5468\u7d44\u7e54\u3092\u58ca\u3059\u75c5\u6c17\u3060\u304b\u3089\u6b6f\u5468\u75c5\u3068\u3044\u3046\u306e\u3067\u3059\u3002<br \/><span style=\"color: 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\/>\u6b6f\u5468\u75c5\u306e\u6016\u3044\u3068\u3053\u308d\u306f\u6b6f\u5468\u306b\u6b62\u307e\u3089\u305a\u3001\u5168\u8eab\u75be\u60a3\u3068\u306e\u95a2\u9023\u304c\u6975\u3081\u3066\u5f37\u3044\u75c5\u6c17\u306a\u306e\u3067\u3059\u3002<br \/>\u306a\u305c\u5acc\u6c17\u6027\u83cc\u304c\u5897\u3048\u308b\u304b\u3068\u3044\u3046\u30682\u3064\u306e\u7406\u7531\u304c\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-8666\" src=\"https:\/\/www.cobaring.com\/wp-content\/uploads\/2023\/10\/20231001_124025.gif\" alt=\"\" width=\"388\" height=\"640\" \/><br \/>1\u3064\u306f\u5168\u7136\u6b6f\u3092\u78e8\u304b\u306a\u3044\u4eba\u3002\u6216\u3044\u306f\u78e8\u3051\u3066\u3044\u308b\u3064\u3082\u308a\u306b\u306a\u3063\u3066\u3044\u308b\u4eba\u3002\u6216\u3044\u306f\u6b6f\u306e\u8868\u9762\u3060\u3051\u78e8\u3044\u3066\u3044\u308b\u3051\u308c\u3069\u6b6f\u3068\u6b6f\u306e\u9593\u3068\u304b\u6b6f\u3068\u6b6f\u830e\u306e\u969b\u3060\u3068\u304b<strong>\u30c7\u30f3\u30bf\u30eb\u30d5\u30ed\u30b9\u3068\u3044\u3046\u306e\u3092\u4f7f\u308f\u306a\u3044\u3068\u53d6\u308c\u306a\u3044\u3068\u3053\u308d\u3092\u4e00\u5207\u3084\u3063\u3066\u3044\u306a\u3044\u3068\u304b\u3068\u3044\u3046\u4eba\u306f\u7d2f\u7a4d\u3057\u3066\u591a\u304f\u306e\u83cc\u304c\u5897\u3048\u3066\u304f\u308b<\/strong>\u306e\u3067\u3059\u3002\u305d\u3057\u3066\u708e\u75c7\u304c\u3060\u3093\u3060\u3093\u5f37\u304f\u306a\u3063\u3066\u304f\u308b\u3068\u5c11\u3057\u305a\u3064\u4e2d\u306b\u5165\u3063\u3066\u304f\u308b\u78ba\u7387\u304c\u9ad8\u304f\u306a\u308a<span style=\"color: darkred;\">\u6162\u6027\u7684\u306b10\uff5e20\u5e74\u3068\u304b\u306b\u306a\u308b\u3068\u60aa\u3044\u30d0\u30a4\u83cc\u3082\u7e41\u6b96\u3057\u3066\u304d\u3066\u6b6f\u5468\u75c5\u304c\u9032\u884c\u3059\u308b<\/span>\u3068\u3044\u3046\u306e\u304c\u4e00\u822c\u7684\u306a\u5834\u5408\u3067\u3059\u3002<br \/><strong>\u611f\u67d3\u75c7\u306a\u306e\u3067\u3059\u304c\u3001\u5b9f\u969b\u306f\u751f\u6d3b\u7fd2\u6163\u75c5\u306a\u306e\u3067\u3059\u3002<\/strong><br \/>\u6b6f\u78e8\u304d\u304c\u6b63\u3057\u304f\u3067\u304d\u3066\u3044\u306a\u3044\u3068\u3053\u3046\u3044\u3063\u305f\u6b6f\u5468\u75c5\u306b\u304b\u304b\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002<br \/>\u3053\u308c\u306f\u6b6f\u79d1\u533b\u9662\u306b\u884c\u3063\u3066\u6b6f\u30d6\u30e9\u30b7\u6307\u5c0e\u3001\u53e3\u8154\u6e05\u6383\u6307\u5c0e\u3092\u3057\u3066\u3082\u3089\u3044\u3001\u521d\u671f\u306e\u6b6f\u77f3\u306a\u3089\u3070\u8d85\u97f3\u6ce2\u306a\u3069\u3067\u53d6\u308a\u9664\u3044\u3066\u3082\u3089\u3044\u3001\u53e3\u306e\u4e2d\u3092\u3067\u304d\u308b\u3060\u3051\u7dba\u9e97\u306b\u3057\u3066\u304a\u304f\u3053\u3068\u304c\u5927\u4e8b\u3067\u3059\u3002<\/p>\n<h2>\u6b6f\u77f3<\/h2>\n<p>\u6b6f\u77f3\u3068\u3044\u3046\u306e\u306f\u553e\u6db2\u4e2d\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u6210\u5206\u304c\u6c5a\u308c\u3068\u4e00\u7dd2\u306b\u7d50\u5408\u3057\u3066\u786c\u304f\u306a\u3063\u3066\u3057\u307e\u3046\u73fe\u8c61\u306a\u306e\u3067\u3059\u3002<br \/>\u307e\u305f<span style=\"color: coral;\">\u708e\u75c7\u304c\u5f37\u3044\u3068\u3053\u308d\u306b\u5fc5\u305a\u30ab\u30eb\u30b7\u30a6\u30e0\u304c\u6ca2\u5c71\u4ed8\u304f\u306e\u3067\u3059\u3002<br \/>\u814e\u81d3\u7d50\u77f3\u3068\u304b\u80c6\u56a2\u7d50\u77f3\u3068\u304b\u3082\u540c\u69d8\u306a\u306e\u3067\u3059\u3002\u708e\u75c7\u304c\u3042\u308b\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u304c\u6c88\u7740\u3057\u3084\u3059\u304f\u306a\u308b\u306e\u3067\u3059\u3002<\/span><br \/>\u7279\u306b\u820c\u4e0b\u817a\u3068\u304b\u984e\u4e0b\u817a\u3068\u3044\u3046\u306e\u304c\u53e3\u304b\u3089\u51fa\u307e\u3059\u304c\u3001\u4e0b\u306e\u6b6f\u306e\u5185\u5074\u306b\u306f\u6b6f\u77f3\u304c\u4ed8\u304d\u3084\u3059\u3044\u3067\u3059\u3057\u3001\u7b2c\u4e00\u5927\u81fc\u6b6f\u306e\u8fba\u308a\u3068\u3044\u3046\u306e\u306f\u6b6f\u77f3\u304c\u3068\u3066\u3082\u6e9c\u307e\u308a\u3084\u3059\u3044\u306e\u3067\u3059\u3002<br \/>\u304d\u3061\u3093\u3068\u6307\u5c0e\u3092\u53d7\u3051\u3066\u4ed8\u3044\u3066\u3044\u308b\u6b6f\u77f3\u3092\u53d6\u3063\u3066\u304a\u3051\u3070\u307b\u3068\u3093\u3069\u9032\u884c\u3059\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h2>\u611f\u67d3\u75c7\u306e\u6b6f\u5468\u75c5<\/h2>\n<p>\u3068\u3053\u308d\u304c\u672c\u5f53\u306e\u611f\u67d3\u75c7\u306e\u6b6f\u5468\u75c5\u3068\u3044\u3046\u306e\u3082\u3042\u308b\u306e\u3067\u3059\u3002<br \/>\u3044\u308f\u3086\u308b<strong>\u6b6f\u5468\u75c5\u83cc\u306e\u60aa\u7389\u83cc<\/strong>\u3067\u3059\u3002\u9aa8\u3092\u3082\u306e\u3059\u3054\u304f\u6eb6\u304b\u3059\u30d0\u30a4\u83cc\u3068\u304b\u6b6f\u8089\u3092\u3082\u306e\u3059\u3054\u304f\u51fa\u8840\u3055\u305b\u308b\u30d0\u30a4\u83cc\u3067\u3059\u3068\u304b\u3001\u4ed6\u306b\u3082<strong>\u904b\u52d5\u6027\u687f\u83cc<\/strong>\u3068\u3044\u3063\u3066\u3046\u304c\u3044\u85ac\u3068\u304b\u6d88\u6bd2\u85ac\u3068\u304b\u3092\u4f7f\u7528\u3057\u3066\u3082\u9003\u3052\u3066\u3057\u307e\u3044\u3001<strong>\u30a4\u30bd\u30b8\u30f3\u3084\u30ea\u30b9\u30c6\u30ea\u30f3\u306a\u3069\u3067\u8868\u9762\u3060\u3051\u7dba\u9e97\u306b\u3057\u3066\u3082\u6df1\u3044\u3068\u3053\u308d\u306b\u9003\u3052\u3066\u3044\u304f\u305f\u3081\u3088\u308a\u4e00\u5c64\u60aa\u304f\u306a\u308b\u3088\u3046\u306a\u30d0\u30a4\u83cc\u304c\u3044\u308b<\/strong>\u306e\u3067\u3059\u3002<br \/>\u3053\u3046\u3044\u3046\u6b6f\u5468\u75c5\u306f\u611f\u67d3\u75c7\u306a\u306e\u3067\u3059\u3002\u6027\u611f\u67d3\u75c7\u306e\u3088\u3046\u306b\u6885\u6bd2\u3068\u304b\u6dcb\u75c5\u306e\u3088\u3046\u306b\u4fdd\u83cc\u3057\u3066\u3044\u308b\u4eba\u540c\u58eb\u304c\u6027\u884c\u70ba\u3092\u3059\u308b\u3068\u3046\u3064\u308b\u306e\u304c\u6027\u75c5\u3067\u3059\u304c\u3001\u6b6f\u5468\u75c5\u306f\u5c02\u9580\u7684\u306b\u3044\u3046\u3068\u30dd\u30eb\u30d5\u30a3\u30ce\u30e2\u30ca\u30b9\u30fb\u30b8\u30f3\u30b8\u30d0\u30ea\u30b9\uff08Porphyromonas gingivalis\uff09\u3068\u304b\u30a2\u30b0\u30ea\u30b2\u30a4\u30c6\u30a3\u30d0\u30af\u30bf\u30fc\u30fb\u30a2\u30af\u30c1\u30ce\u30df\u30bb\u30c6\u30e0\u30b3\u30df\u30bf\u30f3\u30b9\uff08Aggregatibacter actinomycetemcomitans\uff09\u3068\u304b\u30c8\u30ec\u30dd\u30cd\u30fc\u30de\u30c7\u30f3\u30c6\u30a3\u30b3\u30fc\u30e9\uff08Treponema denticola\uff09\u306a\u3069\u304c\u3042\u308b\u306e\u3067\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u30d0\u30a4\u83cc\u306f\u3044\u3064\u3046\u3064\u308b\u304b\u306a\u306e\u3067\u3059\u3002<br \/>\u611f\u67d3\u306e\u7a93\u30a4\u30f3\u30d5\u30a7\u30af\u30b7\u30e7\u30ca\u30eb\u30a6\u30a4\u30f3\u30c9\u30a6\uff08Infectional window\uff09\u3068\u3044\u3063\u3066\u7a93\u304c\u958b\u3044\u3066\u3044\u308b\u3068\u304d\u3060\u3051\u611f\u67d3\u3059\u308b\u306e\u3067\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-8667\" src=\"https:\/\/www.cobaring.com\/wp-content\/uploads\/2023\/10\/20231001_123840.gif\" alt=\"\" width=\"388\" height=\"640\" \/><br \/>\u3053\u308c\u306f\u5927\u4f536\u6b73\u524d\u5f8c\u306a\u306e\u3067\u3059\u3002\u3068\u3044\u3046\u306e\u306f\u4e73\u6b6f\u3068\u3044\u3046\u306e\u306f\u6b6f\u304c\u306a\u3044\u3068\u3053\u308d\u306b\u751f\u3048\u3066\u304f\u308b\u308f\u3051\u306a\u306e\u3067\u3059\u304c\u3001\u7279\u306b\u4e0b\u306e\u6b6f\u306e\u524d\u6b6f\u304c\u76f8\u5f53\u3057\u307e\u3059\u304c\u3001\u751f\u3048\u51fa\u3057\u3066\u304f\u308b\u3068\u767d\u304f\u900f\u3051\u3066\u898b\u3048\u307e\u3059\u3002\u3084\u304c\u3066\u7a81\u304d\u7834\u3063\u3066\u6b6f\u304c\u51fa\u3066\u304d\u307e\u3059\u3002\u3068\u3053\u308d\u304c\u6b6f\u306e\u8868\u9762\u306b\u306f\u30a8\u30ca\u30e1\u30eb\u4e0a\u76ae\u3068\u3044\u3063\u3066\u76ae\u819a\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308b\u305f\u3081\u3001\u305a\u3063\u3068\u76ae\u819a\u306e\u3088\u3046\u306a\u3082\u306e\u3068\u7e4b\u304c\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u305d\u308c\u304c\u6b6f\u304c\u751f\u3048\u304d\u3063\u305f\u3068\u3053\u308d\u3067\u6b62\u307e\u308b\u3068\u6b6f\u306e\u8868\u9762\u306b\u76ae\u819a\u3068\u540c\u3058\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308a\u3001\u305d\u308c\u304c\u6b6f\u8089\u3068\u7e4b\u304c\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u3002<br \/>\u3068\u3053\u308d\u304c\u5f90\u3005\u306b\u4e0a\u76ae\u3068\u304b\u304c\u53d6\u308c\u3066\u304f\u308b\u3068\u3001\u3053\u306e\u30a8\u30ca\u30e1\u30eb\u8cea\u306e\u4e00\u756a\u4e0b\u306e\u3068\u3053\u308d\u3068\u6b6f\u8089\u3068\u3044\u3046\u4e0a\u76ae\u304c\u5bc6\u7740\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u3053\u308c\u3092\u30d8\u30df\u30c7\u30b9\u30e2\u30be\u30fc\u30e0\u7d50\u5408\uff08hemidesmosome junction\uff09\u3068\u3044\u3046\u306e\u3067\u3059\u304c\u3001\u4e0a\u76ae\u3068\u4e0a\u76ae\u306e\u7d50\u5408\u306a\u306e\u3067\u3059\u3002<br \/>\u4e0a\u76ae\u306e\u7d50\u5408\u304c\u58ca\u308c\u3066\u3044\u308b\u3068\u3044\u3046\u306e\u306f\u80c3\u306b\u7a74\u304c\u958b\u3044\u3066\u3044\u308b\u80c3\u6f70\u760d\u306e\u3088\u3046\u306a\u72b6\u6cc1\u3068\u540c\u3058\u76ae\u819a\u306b\u7a74\u304c\u958b\u3044\u3066\u308b\u3001\u3044\u308f\u3070\u602a\u6211\u3092\u3057\u3066\u4e2d\u306e\u7b4b\u8089\u304c\u898b\u3048\u305f\u308a\u3068\u304b\u3057\u3066\u3044\u308b\u3088\u3046\u306a\u72b6\u6cc1\u306a\u306e\u3067\u3059\u304c\u3001\u4e73\u6b6f\u306e\u3068\u304d\u3068\u3044\u3046\u306e\u306f\u4e0a\u76ae\u306e\u6b20\u843d\u304c\u306a\u3044\u306e\u3067\u5f53\u7136\u6b6f\u5468\u75c5\u306b\u306a\u3089\u306a\u3044\u306e\u3067\u3059\u3002\u866b\u6b6f\u306b\u306a\u3063\u3066\u3082\u6b6f\u5468\u75c5\u306b\u306a\u3089\u306a\u3044\u306e\u3067\u3059\u3002<br \/>\u5acc\u6c17\u6027\u83cc\u3068\u3044\u3046\u7a7a\u6c17\u306e\u306a\u3044\u7d30\u83cc\u3068\u3044\u3046\u306e\u304c\u5897\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u306e\u3067\u3059\u3002<br \/>\u4e73\u6b6f\u3067\u6b6f\u5468\u75c5\u306e\u4eba\u3068\u3044\u3046\u306e\u306f\u4f59\u7a0b\u7279\u5225\u306a\u5834\u5408\u3067\u306a\u3044\u3068\u3042\u308a\u307e\u305b\u3093\u3002<br \/>\u3068\u3053\u308d\u304c\u3053\u306e\u4e73\u6b6f\u304c\u751f\u3048\u7d42\u308f\u3063\u305f\u3089\u5f8c\u304b\u3089\u6c38\u4e45\u6b6f\u304c\u751f\u3048\u3066\u304f\u308b\u308f\u3051\u3067\u3059\u3002\u6c38\u4e45\u6b6f\u306f\u4e73\u6b6f\u306b\u6bd4\u3079\u3066\u3082\u306e\u3059\u3054\u304f\u786c\u304f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u7d50\u6676\u5ea6\u304c\u9ad8\u3044\u306e\u3067\u3059\u3002\u9006\u306b\u4e73\u6b6f\u306f\u5f31\u3044\u306e\u3067\u5f53\u305f\u3063\u3066\u304f\u308b\u3068\u5438\u53ce\u3055\u308c\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u6700\u5f8c\u306e\u6700\u5f8c\u306b\u306a\u308b\u3068\u4e73\u6b6f\u306e\u6839\u3063\u3053\u304c\u306a\u304f\u306a\u3063\u3066\u3001\u982d\u3060\u3051\u304c\u30dd\u30ed\u30f3\u3068\u53d6\u308c\u308b\u72b6\u6cc1\u306b\u306a\u308a\u307e\u3059\u3002<br \/>\u4e73\u6b6f\u304c\u6839\u3063\u3053\u304b\u3089\u629c\u3051\u306a\u3044\u306e\u306f\u305d\u3046\u3044\u3063\u305f\u7406\u7531\u304c\u3042\u308b\u304b\u3089\u3067\u3059\u3002\u6b6f\u306e\u982d\u3060\u3051\u304c\u53d6\u308c\u308b\u3002\u305d\u3046\u3059\u308b\u3068\u4e0a\u76ae\u304c\u6b20\u843d\u304c\u3042\u308a\u307e\u3059\u3002\u4e73\u6b6f\u304c\u629c\u3051\u308b\u3068\u304d\u306f\u5fc5\u305a\u51fa\u8840\u3057\u307e\u3059\u3002\u80c3\u6f70\u760d\u3068\u540c\u3058\u3088\u3046\u306a\u72b6\u6cc1\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u3002<br \/>\u8840\u3092\u597d\u3080\u7d30\u83cc\u3068\u304b\u86cb\u767d\u8cea\u3092\u5206\u89e3\u3059\u308b\u306e\u3092\u597d\u3080\u7d30\u83cc\u3068\u304b\u304c\u3078\u3070\u308a\u4ed8\u304f\u306e\u3067\u3059\u3002\u3082\u3063\u3068\u3082\u3001\u305d\u306e\u30d0\u30a4\u83cc\u304c\u3044\u306a\u3051\u308c\u3070\u6b6f\u5468\u75c5\u83cc\u304c\u68f2\u3080\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002<br \/>\u3067\u306f\u305d\u306e<span style=\"color: coral;\">\u6b6f\u5468\u75c5\u83cc\u306f<\/span>\u8ab0\u304b\u3089\u3082\u3089\u3063\u3066\u3044\u308b\u306e\u304b\u3068\u3044\u3046\u3068\u3001\u591a\u304f\u306e\u5834\u5408\u306f<span style=\"color: coral;\">\u6bcd\u89aa\u3067\u3042\u3063\u305f\u308a\u3001\u7956\u6bcd\u3067\u3042\u3063\u305f\u308a\u3057\u305f\u306e\u3067\u3059\u3002<\/span>\u6b6f\u5468\u75c5\u83cc\u3092\u3082\u3063\u305f\u4eba\u304c\u5341\u5206\u5480\u56bc\u3067\u304d\u306a\u3044\u5b50\u4f9b\u306b\u4ee3\u308f\u3063\u3066\u565b\u307f\u7815\u3044\u305f\u3082\u306e\u3092\u4e0e\u3048\u305f\u308a\u3059\u308b\u3053\u3068\u30675\uff5e6\u6b73\u3050\u3089\u3044\u306b\u4f1d\u67d3\u3057\u3066\u3044\u304f\u306e\u3067\u3059\u3002<br \/>\u3053\u3046\u3044\u3046\u6b6f\u5468\u75c5\u306b\u306a\u3063\u305f\u4eba\u3092\u82e5\u5e74\u6027\u6b6f\u5468\u708e\u3068\u3044\u3044\u307e\u3059\u3002<br \/>\u5927\u4f536\uff5e\uff18\u6b73\u3067\u6b6f\u5468\u75c5\u304c\u9032\u884c\u3057\u305f\u4eba\u3067\u6700\u521d\u306b\u751f\u3048\u3066\u304f\u308b\u6b6f\u3068\u3044\u3046\u306e\u306f\u4e0b\u306e\u6b6f\u306e\u524d\u6b6f\u3067\u3059\u3002\u305d\u306e\u6b21\u304c\u4e0a\u306e\u6b6f\u306e\u524d\u6b6f\u306a\u306e\u3067\u3001\u305d\u3053\u306b\u5c40\u9650\u3057\u3066\u6b6f\u5468\u75c5\u304c\u8d77\u3053\u308a\u307e\u3059\u3002<br \/>\u5c0f\u5b66\u751f\u306e1\uff5e2\u5e74\u751f\u3050\u3089\u3044\u3067\u3001\u6216\u3044\u306f\u305d\u306e\u6b21\u3050\u3089\u3044\u306b\u5927\u81fc\u6b6f\u3068\u3044\u3046\u306e\u304c\u5f8c\u308d\u306b\u751f\u3048\u3066\u304f\u308b\u306e\u3067\u3059\u3002\u305d\u3053\u306b\u3082\u540c\u3058\u3088\u3046\u306b\u611f\u67d3\u3057\u3066\u7b2c\u4e00\u5927\u81fc\u6b6f\u3068\u524d\u6b6f\u3068\u3044\u3046\u306e\u3060\u3051\u304c\u7279\u7570\u7684\u306b\u6b6f\u5468\u75c5\u304c\u60aa\u3044\u3068\u3044\u3046\u306e\u3092\u5c40\u9650\u578b\u82e5\u5e74\u6027\u6b6f\u5468\u708e\u3068\u3044\u3046\u3075\u3046\u306b\u6614\u306f\u8a00\u3063\u3066\u3044\u307e\u3057\u305f\u3002<br \/>\u5168\u90e8\u4e73\u6b6f\u304c\u629c\u3051\u843d\u3061\u3066\u3057\u307e\u3044\u3001\u6b21\u306b\u6c38\u4e45\u6b6f\u304c\u751f\u3048\u63c3\u3063\u3066\u3057\u307e\u3046\u3068\u3001\u4e00\u65e6\u6b6f\u5468\u75c5\u306f\u6b62\u307e\u308a\u307e\u3059\u3002\u305d\u308c\u306f\u8840\u6db2\u304c\u51fa\u308b\u72b6\u614b\u3067\u306f\u306a\u304f\u306a\u308b\u304b\u3089\u3067\u3059\u3002<br \/>\u6b21\u306b\u3069\u3046\u306a\u308b\u306e\u304b\u3068\u3044\u3046\u3068\u3001\u89aa\u77e5\u3089\u305a\u304c\u751f\u3048\u3066\u304f\u308b\u6642\u306b\u540c\u3058\u3088\u3046\u306a\u72b6\u6cc1\u306b\u306a\u308b\u306e\u3067\u3059\u3002<strong>20\u4ee3\u5f8c\u534a\u304b\u308930\u4ee3\u524d\u534a\u3050\u3089\u3044\u3067\u6025\u306b\u6b6f\u5468\u75c5\u83cc\u304c\u5897\u6b96\u3092\u59cb\u3081\u308b<\/strong>\u306e\u3067\u3059\u3002\u3053\u308c\u3092<span style=\"color: coral;\">\u6025\u901f\u9032\u884c\u6027\u6b6f\u5468\u708e<\/span>\u3068\u3044\u3044\u307e\u3059\u3002\u30a2\u30b0\u30ec\u30c3\u30b7\u30d6\u30da\u30ea\u30aa\u30c9\u30f3\u30bf\u30a4\u30c6\u30a3\u30b9\uff08Aggressive Periodontaitis\uff09\u3068\u82f1\u8a9e\u3067\u306f\u8868\u73fe\u3057\u307e\u3059\u3002<br \/>\u5148\u7a0b\u306e\u5c40\u9650\u578b\u82e5\u5e74\u6027\u6b6f\u5468\u708e\u306f\u30ed\u30fc\u30ab\u30e9\u30a4\u30ba\u30c9\u30b7\u30e5\u30d9\u30ca\u30fc\u30eb\u30da\u30ea\u30aa\u30c9\u30f3\u30bf\u30a4\u30c6\u30a3\u30b9\uff08Localized juvenile periodontitis \uff09\u3068\u3044\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u6b6f\u5468\u75c5\u306b\u306a\u308b\u3068\u6b6f\u5468\u75c5\u306b\u611f\u67d3\u3057\u305f\u3068\u3044\u3046\u3053\u3068\u306a\u306e\u3067\u3059\u3002<br \/>\u4f8b\u3048\u3070\u7236\u89aa\u3084\u6bcd\u89aa\u3068\u3044\u3063\u305f<strong>\u89aa\u5fa1\u3055\u3093\u304c\u6b6f\u5468\u75c5\u3067\u3059\u3068\u5b50\u4f9b\u304c5\uff5e6\u6b73\u3050\u3089\u3044\u306e\u4e73\u6b6f\u304c\u751f\u3048\u5909\u308f\u308b\u3068\u304d\u306f\u3001\u7279\u306b\u6c17\u3092\u4ed8\u3051\u306a\u304f\u3066\u306f\u306a\u3089\u306a\u3044\u306e\u3067\u3059\u3002<\/strong>\u76ee\u3092\u96e2\u3057\u305f\u9699\u306b\u6b6f\u5468\u75c5\u307e\u307f\u308c\u306e\u7956\u6bcd\u306b\u6b6f\u5468\u75c5\u83cc\u306b\u6c5a\u67d3\u3055\u308c\u305f\u98df\u3079\u7269\u3084\u30b9\u30d7\u30fc\u30f3\u3067\u98df\u4e8b\u3092\u3092\u4e0e\u3048\u3089\u308c\u3066\u3044\u306a\u3044\u304b\u6ce8\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\u3053\u3093\u306a\u8a71\u3082\u3042\u308a\u307e\u3059\u3002\u4eba\u9593\u304b\u3089\u6b6f\u5468\u75c5\u83cc\u304c\u72ac\u306b\u611f\u67d3\u3057\u3066\u6b6f\u5468\u75c5\u306b\u306a\u308b\u3053\u3068\u306f\u306a\u3044\u306e\u3067\u3059\u304c\u3001\u9810\u3051\u3089\u308c\u305f\u4fdd\u83cc\u72ac\u304b\u3089\u4eba\u9593\u306e\u6b6f\u5468\u75c5\u304c\u611f\u67d3\u3057\u305f\u3068\u3044\u3046\u3053\u3068\u304c\u3042\u308a\u307e\u3057\u305f\u3002<br \/>\u6216\u3044\u306f\u30d7\u30ed\u30d0\u30f3\u30c9\uff08proband \uff09\u3068\u3044\u3046\u8003\u3048\u65b9\u3067\u3001\u30d1\u30fc\u30c8\u30ca\u30fc\u306e\u7247\u65b9\u304c\u91cd\u75c7\u306a\u6b6f\u5468\u75c5\u83cc\u3092\u6301\u3063\u3066\u3044\u3066\u7247\u65b9\u304c\u3046\u3064\u3089\u306a\u3044\u4f8b\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\u5acc\u6c17\u6027\u83cc\u306f\u5897\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u304c\u3001\u3042\u308b\u30d1\u30fc\u30c8\u30ca\u30fc\u304c\u91cd\u75c7\u306a\u6b6f\u5468\u75c5\u83cc\u3092\u6301\u3063\u3066\u3044\u305f\u5834\u5408\u3001\u6b6f\u78e8\u304d\u4e0d\u8db3\u3067\u30dd\u30b1\u30c3\u30c8\u304c\u6df1\u304f\u306a\u3063\u3066\u3044\u308b\u4eba\u306f\u611f\u67d3\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002<br \/>\u3053\u306e\u5143\u306e\u4eba\u306e\u3053\u3068\u3092\u533b\u5b66\u7528\u8a9e\u3067\u30d7\u30ed\u30d0\u30f3\u30c9\u3068\u3044\u3044\u307e\u3059\u3002<br \/>\u3053\u306e\u30d7\u30ed\u30d0\u30f3\u30c9\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u304c1980\uff5e1990\u5e74\u4ee3\u306b\u6ca2\u5c71\u51fa\u3066\u3044\u3066\u5409\u91ce\u5148\u751f\u306e\u5c02\u9580\u5206\u91ce\u3067\u3044\u304f\u3064\u304b\u306e\u8457\u66f8\u3082\u4e0a\u6893\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002<br \/>\u7d30\u83cc\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u6614\u306f\u57f9\u990a\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u975e\u5e38\u306b\u9ad8\u5ea6\u3067\u3042\u308b\u305f\u3081\u7c21\u5358\u306b\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002<br \/>\u305d\u3053\u3067\u958b\u767a\u3055\u308c\u305f\u306e\u304cPCR\u6cd5\u3060\u3063\u305f\u306e\u3067\u3059\u3002\u305d\u308c\u30921999\u5e74\u304b\u3089\u65e5\u672c\u3067\u6700\u521d\u306b\u533b\u5e2b\u30fb\u6b6f\u79d1\u533b\u5e2b\u3082\u542b\u3081\u3066\u81e8\u5e8a\u306b\u5c0e\u5165\u3057\u3066\u81ea\u7531\u8a3a\u7642\u3067\u3057\u304b\u3067\u304d\u306a\u3044\u305f\u3081\u59cb\u3081\u308b\u3053\u3068\u306b\u3057\u305f\u306e\u3067\u3059\u3002<br \/>\u5b66\u4f1a\u767a\u8868\u3060\u3051\u306754\u56de\u3082\u884c\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u305d\u3053\u304b\u3089\u6559\u79d1\u66f8\u3092\u4f5c\u3063\u305f\u7d4c\u7def\u304c\u3042\u308a\u307e\u3057\u305f\u3002<br \/>\u7d50\u5c40<span style=\"color: coral;\">\u6b6f\u5468\u75c5\u3068\u3044\u3046\u306e\u306f\u624b\u5165\u308c\u4e0d\u8db3\u3067\u306a\u3063\u3066\u3044\u308b\u3082\u306e\u3068\u611f\u67d3\u75c7\u306e\u3082\u306e\u3068\u304c\u3042\u308b<\/span>\u3068\u3044\u3046\u3053\u3068\u306a\u306e\u3067\u3059\u3002<br \/>\u3064\u307e\u308a\u81ea\u5206\u304c\u3082\u3057\u611f\u67d3\u75c7\u306e\u5834\u5408\u306f\u5f53\u7136\u4eba\u306b\u3046\u3064\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3067\u3001<span style=\"color: coral;\">\u4ea4\u969b\u3057\u305f\u308a\u7d50\u5a5a\u3057\u305f\u308a\u3059\u308b\u524d\u306b\u6cbb\u7642\u3057\u3001\u6216\u3044\u306f\u4fdd\u5b58\u3067\u304d\u306a\u3044\u6b6f\u3067\u3057\u305f\u3089\u629c\u6b6f\u3057\u3066\u6b6f\u5468\u75c5\u83cc\u304c\u3044\u306a\u3044\u72b6\u614b\u306b\u3057\u3066\u30d1\u30fc\u30c8\u30ca\u30fc\u306b\u611f\u67d3\u3057\u306a\u3044\u3088\u3046\u306b\u3057\u3066\u3042\u3052\u308c\u3070\u5b50\u4f9b\u306b\u3046\u3064\u3059\u53ef\u80fd\u6027\u304c\u306a\u304f\u306a\u308a\u307e\u3059\u3002<\/span><br \/>\u307e\u305f\u8eab\u5185\u306b\u6b6f\u5468\u75c5\u306e\u4eba\u304c\u3044\u308b\u5834\u5408\u306f\u30b9\u30d7\u30fc\u30f3\u306a\u3069\u3092\u5171\u7528\u3057\u306a\u3044\u3088\u3046\u306b\u5236\u9650\u3092\u304b\u3051\u308b\u3053\u3068\u3067\u611f\u67d3\u3092\u56de\u907f\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002<br \/>\u56e0\u307f\u306b\u7a7a\u6c17\u611f\u67d3\u3084\u98db\u6cab\u611f\u67d3\u306f\u3057\u307e\u305b\u3093\u3002\u5acc\u6c17\u6027\u83cc\u3068\u3044\u3046\u306e\u306f\u7a7a\u6c17\u306b\u6652\u3055\u308c\u308b\u3068\u3046\u3064\u3089\u306a\u3044\u304b\u3089\u3067\u3059\u3002<br \/>\u6240\u8b02\u6fc3\u539a\u553e\u6db2\u63a5\u89e6\u3067\u3046\u3064\u308b\u306e\u3067\u3059\u3002\u30d5\u30ec\u30f3\u30c1\u30fb\u30ad\u30b9\u7a0b\u5ea6\u3067\u306f\u3046\u3064\u308a\u307e\u305b\u3093\u304c\u3001\u30c7\u30a3\u30fc\u30d7\u30ad\u30b9\u3067\u3059\u3068\u3046\u3064\u308a\u307e\u3059\u3002<br \/>\u305f\u3060\u5148\u7a0b\u3082\u89e6\u308c\u307e\u3057\u305f\u304c\u3001\u76f8\u624b\u306e\u7a7a\u6c17\u304c\u5acc\u6c17\u6027\u6b6f\u5468\u75c5\u83cc\u304c\u5897\u3048\u306a\u3044\u3088\u3046\u306a\u74b0\u5883\u3067\u3042\u308c\u3070\u3001\u5bb9\u6613\u306b\u3046\u3064\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002<br \/>\u3068\u3053\u308d\u304c\u5bb6\u65cf\u5185\u3067\u3082\u6fc3\u539a\u553e\u6db2\u63a5\u89e6\u3092\u983b\u56de\u306b\u7e70\u308a\u8fd4\u3059\u3088\u3046\u306a\u74b0\u5883\u3068\u3044\u3046\u306e\u306f\u57fa\u672c\u306f\u604b\u4eba\u3084\u592b\u5a66\u3068\u3044\u3063\u305f\u30d1\u30fc\u30c8\u30ca\u30fc\u3067\u3059\u3002<br \/>\u540c\u6027\u540c\u58eb\u3067\u3082\u8d77\u3053\u308a\u5f97\u307e\u3059\u3002\u305d\u3046\u306a\u3089\u306a\u3044\u3088\u3046\u306a\u7814\u7a76\u3068\u304bDNA\u3067\u306e\u691c\u67fb\u306e\u4ed5\u65b9\u3068\u3044\u3046\u306e\u3092\u5409\u91ce\u5148\u751f\u306f\u305a\u3063\u3068\u7d9a\u3051\u3066\u304d\u305f\u305d\u3046\u3067\u3059\u3002<\/p>\n<h2>\u4e0a\u533b\u30fb\u4e2d\u533b\u30fb\u4e0b\u533b\u306e\u6cbb\u7642<\/h2>\n<p>\u4e0a\u533b\u30fb\u4e0b\u533b\u306e\u6cbb\u7642\u306e\u8a71\u306b\u306a\u308a\u307e\u3059\u304c1980\u5e74\u4ee3\u306e\u4e0b\u533b\u306e\u6cbb\u7642\u3060\u3068\u300c\u6b6f\u5468\u75c5\u83cc\u3092\u6297\u751f\u7269\u8cea\u3067\u53e9\u304d\u307e\u3057\u3087\u3046\u300d\u3068\u3044\u3046\u8a71\u306b\u306a\u308a\u307e\u3059\u3002<br \/>\u5409\u91ce\u5148\u751f\u306e\u884c\u3063\u305fPCR\u691c\u67fb\u6216\u3044\u306fDNA\u30d6\u30ed\u30fc\u30d6\u3068\u3044\u3046DNA\u3067\u8abf\u3079\u308b\u65b9\u6cd5\u3067\u3059\u3002<br \/>\u907a\u4f1d\u5b50\u7684\u306b\u306f\u7d30\u83cc\u3092\u57f9\u990a\u3059\u308b\u65b9\u6cd5\u3067\u3082\u826f\u3044\u306e\u3067\u3059\u304c\u3001\u8a72\u5f53\u3059\u308b\u83cc\u304c\u5224\u660e\u3057\u305f\u3089\u6297\u751f\u5264\u3067\u53e9\u304f\u3068\u3044\u3046\u9664\u83cc\u65b9\u6cd5\u304b\u30dd\u30d4\u30e5\u30e9\u30fc\u306b\u306a\u3063\u305f\u306e\u3067\u3059\u3002<br \/>\u3068\u306f\u3044\u3048\u539f\u56e0\u3092\u9664\u53bb\u3057\u306a\u3051\u308c\u3070\u518d\u3073\u7d30\u83cc\u306f\u7e41\u6b96\u3059\u308b\u306e\u3067\u30ad\u30ea\u304c\u306a\u3044\u306e\u3067\u3059\u304c\u3001\u514d\u75ab\u529b\u304c\u4f4e\u3044\u3053\u3068\u3092\u7406\u7531\u306b\u3057\u3066\u304f\u308b\u4eba\u304c\u3044\u308b\u306e\u3067\u3059\u3002<br \/>\u6b6f\u5468\u75c5\u83cc\u3092\u3084\u3063\u3064\u3051\u308b\u6297\u4f53\u3084\u767d\u8840\u7403\u304c\u51fa\u305b\u306a\u3044\u3001\u4e00\u756a\u591a\u3044\u306e\u304c\u7cd6\u5c3f\u75c5\u3067\u3059\u3002<br \/>\u6b6f\u5468\u75c5\u3068\u7cd6\u5c3f\u75c5\u306f\u3068\u3066\u3082\u95a2\u4fc2\u304c\u3042\u308a\u3001\u6b6f\u5468\u75c5\u306b\u306a\u308b\u3068IFN-\u03b3\u3068\u304bTNF-\u03b1\u3068\u3044\u3046\u7269\u8cea\u3092\u51fa\u3059\u306e\u3067\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u7269\u8cea\u304c\u51fa\u308b\u3068\u81b5\u81d3\u306e\u30e9\u30f3\u30b1\u30b2\u30eb\u30cf\u30f3\u30b9\u5cf6\u3092\u653b\u6483\u3057\u3001\u30a4\u30f3\u30b7\u30e5\u30ea\u30f3\u3092\u51fa\u306b\u304f\u304f\u3057\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002<br \/>\u3053\u308c\u306b\u3088\u3063\u3066\u7cd6\u5c3f\u75c5\u304c\u9032\u884c\u3057\u3001\u7cd6\u5c3f\u75c5\u304c\u9032\u884c\u3059\u308b\u3068\u51fa\u8840\u3057\u3084\u3059\u304f\u306a\u308b\u306e\u3067\u3001\u307e\u305f\u6b6f\u5468\u75c5\u3082\u60aa\u304f\u306a\u308b\u3068\u3044\u3046\u9023\u9396\u53cd\u5fdc\u304c\u8d77\u304d\u3066\u304f\u308b\u306e\u3067\u3059\u3002<br \/>\u305d\u308c\u3067\u5409\u91ce\u5148\u751f\u306f<strong>\u4e00\u578b\u7cd6\u5c3f\u75c5\u6cbb\u7642\u5c02\u9580\u533b<\/strong>\u3068\u3044\u3046\u8cc7\u683c\u3092\u6301\u3063\u3066\u3044\u308b\u305d\u3046\u3067\u3059\u3002\u3053\u306e\u8cc7\u683c\u306f\u6b6f\u79d1\u533b\u5e2b\u306e\u4e2d\u3067\u306f\u975e\u5e38\u306b\u5e0c\u5c11\u3067\u30a4\u30f3\u30b7\u30e5\u30ea\u30f3\u3092\u51e6\u65b9\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u3082\u53ef\u80fd\u306a\u306e\u3067\u3059\u3002<br \/>\u305d\u306e\u3088\u3046\u306b\u5168\u8eab\u75be\u60a3\u3092\u8a3a\u308b\u3088\u3046\u306b\u306a\u308b\u3068\u3001\u6216\u3044\u306f<span style=\"color: coral;\">\u6b6f\u5468\u75c5\u3068\u304b\u306b\u306a\u308b\u3068\u30b8\u30f3\u30b8\u30d1\u30a4\u30f3\u3068\u304b\u30b3\u30e9\u30b2\u30ca\u30fc\u30bc\u3068\u304b\u3067\u86cb\u767d\u5206\u89e3\u9175\u7d20\u3092\u51fa\u3059\u3088\u3046\u306a\u6b6f\u5468\u75c5\u83cc\u304c\u3044\u308b\u3068\u8840\u7ba1\u5185\u306b\u305d\u306e\u6b6f\u5468\u75c5\u83cc\u304c\u5165\u3063\u3066\u304f\u308b\u306e\u3067\u3059\u3002<br \/>\u7279\u306b\u30dd\u30d5\u30a3\u30ce\u30e2\u30ca\u30b9\u30fb\u30b8\u30f3\u30b8\u30d0\u30ea\u30b9\u3068\u3044\u3046\u7d30\u83cc\u304c\u8840\u7ba1\u5185\u306b\u5165\u3063\u3066\u304f\u308b\u3068\u7d30\u83cc\u6027\u306e\u5fc3\u5185\u819c\u708e\u3068\u304b\u3044\u3046\u306e\u3092\u4f5c\u3063\u305f\u308a\u3068\u304b\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u8d77\u3053\u3059\u306e\u3067\u3059\u3002<br \/>\u9ad8\u8840\u5727\u75c7\u3068\u304b\u8133\u6897\u585e\u3068\u304b\u5fc3\u7b4b\u6897\u585e\u3068\u304b\u5fc3\u4e0d\u5168\u304c\u5897\u3048\u308b<\/span>\u306e\u3067\u3059\u3002<br \/>\u5b9f\u969b\u3001\u91cd\u5ea6\u306e\u8133\u5faa\u74b0\u7cfb\u75be\u60a3\u306e\u60a3\u8005\u306e\u4eba\u3092\u5409\u91ce\u5148\u751f\u304c\u5927\u5b66\u306b\u6240\u5c5e\u3057\u3001\u6025\u6027\u5fc3\u7b4b\u6897\u585e\u306b\u3064\u3044\u3066\u7814\u7a76\u3057\u3066\u3044\u308b\u3068\u304d\u306b\u3001\u305d\u306e\u75c5\u3067\u904b\u3070\u308c\u3066\u304d\u305f\u60a3\u8005\u3092\u63a1\u8840\u3059\u308b\u3068\u6b6f\u5468\u75c5\u83cc\u304c\u62b9\u6d88\u8840\u304b\u3089\u51fa\u3066\u304d\u305f\u305d\u3046\u3067\u3059\u3002\u5f53\u6642\u306e\u540d\u524d\u3067<strong>\u30a2\u30af\u30c1\u30ce\u30d0\u30b7\u30e9\u30b9\u30fb\u30a2\u30af\u30c1\u30ce\u30df\u30bb\u30c6\u30b9\u30b3\u30df\u30bf\u30f3\u30b9\u3068\u3044\u3046\u30d0\u30a4\u83cc\u304c\u3044\u3066\u3001\u3053\u306e\u83cc\u306e\u4fdd\u83cc\u8005\u306f\u6025\u6027\u5fc3\u7b4b\u6897\u585e\u304c\u591a\u3044\u306e\u3067\u3059\u3002\u3053\u308c\u306f\u6b6f\u5468\u75c5\u83cc\u3067\u306a\u3044\u4eba\u306e4\u500d<\/strong>\u306b\u3082\u53ca\u3073\u307e\u3059\u3002<br \/>\u6216\u3044\u306f\u8133\u816b\u760d\u3068\u3044\u3063\u3066\u8133\u810a\u9ac4\u95a2\u9580\u3092\u8d85\u3048\u3066\u3067\u3082\u6b6f\u5468\u75c5\u83cc\u304c\u5165\u3063\u3066\u3057\u307e\u3046\u3053\u3068\u304c\u7a00\u306b\u3042\u308a\u307e\u3059\u30025\uff5e20\u5e74\u6b6f\u5468\u75c5\u3092\u60a3\u3063\u3066\u653e\u7f6e\u3057\u3066\u3044\u308b\u3068\u305d\u3046\u306a\u308b\u3053\u3068\u304c\u3042\u308b\u306e\u3067\u3059\u3002<br \/>\u6216\u3044\u306f\u6b6f\u5468\u75c5\u304c\u9032\u884c\u3059\u308b\u3068\u51fa\u8840\u3059\u308b\u306e\u3067<span style=\"color: coral;\">\u6b6f\u8089\u306e\u51fa\u8840\u3092\u6b62\u3081\u308b\u305f\u3081\u306b\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30c7\u30a3\u30f3E2\uff08Prostaglandin E2\uff09\u3068\u3044\u3046\u7269\u8cea\u3092\u51fa\u3057\u3066\u6bdb\u7d30\u8840\u7ba1\u3092\u7e2e\u3081\u308b\u306e\u3067\u3059\u3002\u3053\u308c\u306f\u305d\u3082\u305d\u3082\u9663\u75db\u4fc3\u9032\u5264\u306e\u305f\u3081\u3001\u65e9\u7523\u3068\u304b\u4f4e\u4f53\u91cd\u51fa\u7523\u3092\u60f9\u304d\u8d77\u3053\u3057\u3084\u3059\u304f\u306a\u308b\u306e\u3067\u3059\u3002<\/span><br \/>\u6b6f\u5468\u75c5\u30dd\u30b1\u30c3\u30c84mm\u4ee5\u4e0a\u3042\u308b\u3082\u306e\u3092\u4f55\u90e8\u4f4d\u304b\u6709\u3057\u3066\u3044\u308b\u4eba\u3068\u55ab\u7159\u8005\u3084\u98f2\u9152\u5e38\u7fd2\u8005\u306e\u3044\u305a\u308c\u304c\u65e9\u7523\u30fb\u4f4e\u4f53\u91cd\u51fa\u7523\u304c\u591a\u3044\u304b\u3068\u3044\u3046\u7814\u7a76\u3067\u306f\u6b6f\u5468\u75c5\u60a3\u8005\u304c\u4e00\u756a\u591a\u3044\u3068\u3044\u3046\u7814\u7a76\u7d50\u679c\u3092\u5f97\u305f\u306e\u3067\u3059\u3002<br \/>\u5409\u91ce\u5148\u751f\u304c\u6b6f\u79d1\u533b\u5e2b\u3067\u3042\u308a\u306a\u304c\u3089\u5168\u8eab\u306e\u3053\u3068\u3092\u8a9e\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u304b\u3068\u3044\u3046\u3068\u3001\u3053\u3046\u3044\u3063\u305f\u7814\u7a76\u3092\u9577\u304f\u7d9a\u3051\u3066\u3053\u3089\u308c\u305f\u304b\u3089\u3060\u305d\u3046\u3067\u3059\u3002<br \/>\u539f\u56e0\u3092\u9664\u53bb\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u3001\u3082\u3068\u3082\u3068\u5409\u91ce\u5148\u751f\u306e\u5bb6\u696d\u304c\u6771\u6d0b\u533b\u5b66\u306e\u6cbb\u7642\u304c\u305d\u306e\u307e\u307e\u6771\u6d0b\u533b\u5b66\u306e\u6cbb\u7642\u3060\u3063\u305f\u304b\u3089\u3060\u305d\u3046\u3067\u3059\u3002<br \/>\u5b9f\u969b\u306b\u4f8b\u3092\u6319\u3052\u308b\u3068\u3001<span style=\"color: coral;\">\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u6b6f\u5468\u75c5\u306e\u624b\u8853\u3092\u3059\u308b\u969b\u306b\u8840\u7cd6\u5024\u3092\u4e0b\u3052\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u304c\u3001\u30a4\u30f3\u30b7\u30e5\u30ea\u30f3\u3067\u4e0b\u3052\u3088\u3046\u3068\u3057\u3066\u3082IFN-\u03b3\u3068\u304bTNF-\u03b1\u304c\u81b5\u81d3\u304b\u3089\u3082\u51fa\u308b\u306e\u3067\u672c\u5f53\u306b\u98df\u4e8b\u7642\u6cd5\u304b\u3089\u3082\u7cd6\u5c3f\u75c5\u3092\u6539\u5584\u3057\u3066\u305d\u3046\u3044\u3063\u305f\u514d\u75ab\u7269\u8cea\u304c\u51fa\u306a\u3044\u3088\u3046\u306b\u3057\u3066\u304b\u3089\u624b\u8853\u3092\u53d7\u3051\u308b\u306e\u304c\u671b\u307e\u3057\u3044\u306e\u3067\u3059\u3002<\/span><br \/>\u6b6f\u5468\u75c5\u306e\u6cbb\u7642\u3092\u3059\u308b\u305f\u3081\u306b\u9ad8\u8840\u5727\u3084\u7cd6\u5c3f\u75c5\u306e\u6cbb\u7642\u3092\u3057\u3066\u304a\u304b\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3068\u304b\u3001\u6216\u3044\u306f\u6d41\u7523\u3092\u7e70\u308a\u8fd4\u3057\u3066\u3044\u308b\u4eba\u306b\u3001\u6d41\u7523\u3055\u305b\u306a\u3044\u3088\u3046\u306b\u6b6f\u5468\u75c5\u306e\u6cbb\u7642\u3092\u3055\u305b\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u5409\u91ce\u5148\u751f\u304c26\uff5e27\u6b73\u306e\u6642\u306b\u3053\u3046\u3057\u305f\u6cbb\u7642\u3092\u59cb\u307e\u308a\u3068\u306a\u3063\u305f\u305d\u3046\u3067\u3059\u3002<br \/>\u3053\u308c\u3089\u306e\u6cbb\u7642\u306f\u5168\u90e8\u4fdd\u967a\u3067\u306f\u3067\u304d\u305a\u3001\u533b\u5e2b\u3068\u6b6f\u79d1\u533b\u5e2b\u306e\u5883\u754c\u306b\u3064\u3044\u3066\u8a71\u3055\u308c\u305f\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\u3001<span style=\"color: coral;\">\u539f\u767a\u304c\u53e3\u8154\u5185\u3067\u3042\u308c\u3070\u3069\u3053\u307e\u3067\u3082\u8ffd\u6c42\u3067\u304d\u308b\u306e\u3067\u3001\u6b6f\u5468\u75c5\u306e\u6cbb\u7642\u3092\u3059\u308b\u306e\u306b\u7cd6\u5c3f\u75c5\u306e\u6cbb\u7642\u306b\u4ecb\u5165\u3059\u308b\u3053\u3068\u304c\u6cd5\u5f8b\u7684\u306b\u3067\u304d\u308b\u306e\u3067\u3059\u3002\u540c\u69d8\u306b\u6b6f\u5468\u75c5\u6cbb\u7642\u3092\u3059\u308b\u306e\u306b\u4e0d\u598a\u6cbb\u7642\u306b\u4ecb\u5165\u3067\u304d\u308b\u306e\u3067\u3059\u3002\u8133\u6897\u585e\u3084\u5fc3\u7b4b\u6897\u585e\u3001\u304f\u3082\u819c\u4e0b\u51fa\u8840\u306e\u6cbb\u7642\u306b\u3064\u3044\u3066\u3082\u540c\u69d8\u306a\u306e\u3067\u3059\u3002<\/span><br \/>\u3053\u3046\u3057\u3066\u5409\u91ce\u5148\u751f\u306f\u8272\u3005\u306a\u3053\u3068\u3092\u898b\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3068\u8a9e\u3063\u3066\u3044\u307e\u3057\u305f\u3002<br \/>\u6b6f\u5468\u75c5\u306f\u6b6f\u3092\u5931\u3063\u3066\u3057\u307e\u3046\u3060\u3051\u306e\u75c5\u3067\u306f\u306a\u3044\u306e\u3067\u3059\u3002<br \/><strong>\u6b6f\u304c\u3050\u3089\u3050\u3089\u3057\u3066\u3044\u305f\u306e\u3067\u6b6f\u78e8\u304d\u6307\u5c0e\u3092\u3057\u305f\u308a\u3001\u3050\u3089\u3050\u3089\u3057\u306a\u3044\u3088\u3046\u306b\u6b6f\u3068\u6b6f\u3092\u7e4b\u3052\u308b\u3068\u3044\u3046\u306e\u306f\u4e0b\u533b\u306e\u6cbb\u7642<\/strong>\u3067\u3059\u3002<br \/>\u6b6f\u5468\u75c5\u304c\u5168\u8eab\u75be\u60a3\u3068\u95a2\u9023\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067<strong>\u8133\u6897\u585e\u3084\u5fc3\u7b4b\u6897\u585e\u306a\u3069\u306e\u6cbb\u7642\u3092\u884c\u3044\u3001\u4e21\u65b9\u304b\u3089\u30a2\u30d7\u30ed\u30fc\u30c1\u3059\u308b\u3053\u3068\u3067\u60a3\u8005\u306eQOL\u3092\u4e0a\u3052\u308b\u3068\u3044\u3046\u306e\u304c\u4e2d\u533b\u306e\u6cbb\u7642<\/strong>\u3067\u3059\u3002<br \/><strong>\u305d\u308c\u3092\u653f\u6cbb\u5bb6\u3068\u3057\u3066\u5e83\u3081\u308b\u3088\u3046\u306b\u3059\u308b\u306e\u304c\u672c\u5f53\u306e\u4e0a\u533b\u306e\u6cbb\u7642<\/strong>\u306a\u306e\u3067\u3059\u3002<br \/><span style=\"color: green;\">\u5409\u91ce\u5148\u751f\u306f\u4eca\u306f\u764c\u306e\u6cbb\u7642\u304c\u591a\u3044\u305d\u3046\u3067\u3059\u304c\u3001\u305d\u306e\u80cc\u666f\u306b\u306f\u539f\u56e0\u9664\u53bb\u7642\u6cd5\u306b\u3088\u308b\u6cbb\u7642\u304c\u6b6f\u5468\u75c5\u306e\u6cbb\u7642\u3068\u540c\u3058\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u764c\u306e\u6cbb\u7642\u306b\u4ecb\u5165\u3059\u308b\u3053\u3068\u306b\u306a\u3063\u305f<\/span>\u306e\u3067\u3059\u3002<br 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